Risk factors for 30-day in-hospital mortality for in-patient with stroke in sub-Saharan Africa: protocol for a systematic review and meta-analysis
Risk factors for 30-day in-hospital mortality for in-patient with stroke in sub-Saharan Africa: protocol for a systematic review and meta-analysis
Blog Article
Introduction While individual studies have reported on in-hospital stroke mortality rates in sub-Saharan Africa (SSA), the estimates are highly variable and inconclusive, buttressing the need for precise and reliable estimations.To overcome these inconsistencies, a well-structured systematic review and meta-analytical models are necessary.However, to the best of our knowledge, there is no published systematic review and meta-analysis on risk factors for 30-day mortality for in-hospital patients with stroke in SSA.Method and analysis We will include all retrospective and prospective facility-based observational studies reporting on the incidence and/or risk factors for in-hospital stroke mortality in SSA.Electronic databases such as PubMed, Google scholar and Africa umcka where to buy Journal Online (AJOL) will be searched for potentially relevant studies on in-hospital stroke mortality and risk factors in SSA.
The search will be limited to studies conducted lutron rrst-8ans-wh from January 1990 to December 2020.Two independent authors will screen titles and abstract to find studies that meet the prespecified eligibility criteria for inclusion in the review.The incidence of 30-day in hospital stroke mortality will be pooled.Meta-regression will be used to assess the factors associated with in-hospital stroke mortality in SSA.If possible, subgroup analysis will be performed based on subregion, publication year and study design, and quality score to determine possible source of heterogeneity.
If possible, a sensitivity analysis will be performed to determine the robustness of the estimates obtained from the meta-analysis.Ethics and dissemination Ethical approval is not required as this is a secondary research and will use reported data in scientific literature.A full manuscript will be submitted to a reputable peer-review journal for publication.PROSPERO registration number CRD42021227367.